Two sample MR report
HLA-DQA1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 48 | 0.3031873 | 0.1806891 | 0.1001395 |
| Weighted median | 48 | -0.2131533 | 0.0312070 | 0.0000000 |
| Inverse variance weighted | 48 | -0.1718559 | 0.0268024 | 0.0000000 |
| Simple mode | 48 | -0.2937780 | 0.0610831 | 0.0000160 |
| Weighted mode | 48 | -0.2854344 | 0.0710068 | 0.0002093 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 76.57358 | 46 | 0.0031016 |
| Inverse variance weighted | 88.30831 | 47 | 0.0002504 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1395386 | 0.0525555 | 0.0108561 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005014 | 1e-07 | TRUE | 0.0352197 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
